https://ogma.newcastle.edu.au/vital/access/ /manager/Index en-au 5 https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:12705 2) appears to be the major determinant of CBF and the factors determining MVo₂ (mainly developed tension and contractile state) are, therefore, major determinants of CBF. The direct effects of autonomic excitation on CBF appear relatively minor, however; the vagus, sympathetic nerves and adrenal medullary hormones profoundly alter CBF indirectly through changes in MVo₂. In the eschaemic heart with atheromatous occlusion of large vessels there is a reduced capacity for autoregulation, and nutrient flow is more dependent on pressure gradient. Hypertension and valvular disorders are often associated with raised MVo₂ but associated abnormalities in pressure gradient and resistance to flow often hinder the supply of CBF needed to meet high demands.]]> Wed 24 Jul 2013 22:24:23 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:12712 Sat 24 Mar 2018 08:16:19 AEDT ]]>